Karela United will be looking to return to winning ways when they host rivals Medeama SC at the Crosby Awuah Memorial Park on Friday.
The Pensioners are coming to the game on the back of a 0-1 defeat against Berekum Chelsea.
Karela United will be determine to avenge the first round defeat against Medeama by beating them at home.
They are currently one of the three teams currently unbeaten at home this season.
The Ayinase based club have won three of their last five home games in the Ghana Premier League.
Medeama SC on the other hand are coming to the game on the back of a 1-0 win over Eleven Wonders.
The Mauves and Yellow side will be determine to complete the double over their rivals.
Medeama have lost their last three games in the league without scoring a goal in any of the games.
Coach Umar Rabi will need his side to play above themselves in order to get something from the game.
Medeama have failed to win in any of their last two visits at the Crosby Awuah Memorial Park.